The CaCO3 and TiO2 factory plays a crucial role in producing these materials on a large scale to meet the growing demand from various industries. The factory utilizes advanced technology and processes to extract and refine CaCO3 and TiO2 from natural resources such as limestone and mineral sands. The production process involves crushing, grinding, and chemical treatment to obtain the desired properties of CaCO3 and TiO2.

Food quality

Matthew Wright, chair of the authority's working group on titanium dioxide, noted that the evidence for general toxic effects was not conclusive, but that the panel couldn't rule out genotoxicity entirely. There were also some current data limitations and the assessment could not establish a safe level for daily intake of the food additive, he stated.

The most significant uncertainty identified by the EU experts was the concern that TiO₂ particles may have genotoxic effects. Genotoxicity refers to the ability of a chemical to directly damage genetic material within a cell (DNA), which may lead to cancer in certain situations. Although the experts did not conclude that TiO₂ particles in E171 are genotoxic, they could not rule out the concern that they might be.

Because of the uncertainty of the impacts of nanoparticles, Made Safe exercises the precautionary principle, meaning we avoid nanoparticles until more extensive scientific testing proves their safety.

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The mineral appears to have low skin penetration, but it is a greater concern when inhaled frequently over time.